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Use of the Cataleptoid Anesthetic CI-744 for Chemical Restraint of Black Bears

Use of the Cataleptoid Anesthetic CI-744 for Chemical Restraint of Black Bears

Warner-Lambert/Parke-Davis and Company have developed a new drug combination known as CI-744 (to be marketed for veterinary use as Tilazol TM). CI-744 is a 1:1 ratio of the phencyclidine hydrochloride (Sernylan) analogue tiletamine hydrochloride and a non-phenothiazine tranquilizer, zolazepam hydrochloride. Field trials of CI-744 in 39 black bears (Ursus americanus) showed its effects to be similar to a 1:1 mixture of Sernylan and promazine hydrochloride. However, CI-744 provides the advantages of shorter restraint time, faster recovery, less salivary and respiratory secretion, and ease of use (no supplemental drugs were needed). Based on 25 immobilizations (22 bears) for which complete and accurate data are available, mean values of 4 important parameters were: induction time, 7 minutes; restraint time, 81 minutes; emergence time, 36 minutes; total down time, 117 minutes. Mean dosage rate was 4.1 mg/kg, but the optimum for routine field work is about 4.0 mg/kg.

  • Author(s) Glenn R. Stewart and John M. Siperek and Vernon R. Wheeler
  • Volume 4
  • Issue
  • Pages 57-61
  • Publication Date 1 January 1980
  • DOI 10.2307/3872843
  • File Size 215.71 KB
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